Cell Adhesion Oligosaccharides

Carbohydrate-mediated cell adhesion is now widely recognized as being important in tissue injury and infection and is almost certainly involved in tumour cell adhesion and metastasis. The Sialyl Lewis^x tetrasaccharide was the first ligand identified in these processes (Philips et al. (1990) Science 250:1132; Lowe et al. (1990) Cell 63: 475). Sialyl Lewis^a has a similar affinity for E, L and P selectins.

More recently the sulphated forms of the Lewis^a and Lewis^x trisaccharides have been shown to exhibit high affinity binding to E-selectin (Yuen et al. (1992) Biochemistry 31: 9126; Green et al. (1992) Biochem. Biophys. Res. Commun. 188: 244).

Dextra now offers these oligosaccharides and a range of neoglycoconjugates.

To permit studies of the effect of multivalency on binding affinity, Dextra has coupled Sialyl Lewis^a and Sialyl Lewis^x to both bovine serum albumin and human serum albumin. In addition, they also offer a conjugate of the Sialyl Lewis^x analogue 3'-Sialyl-3-fucosyl lactose which has been shown to bind effectively to E-selectin (Tyrrell et al. (1991) Proc. Nat. Acad. Sci. USA 88: 10372).

Cell Adhesion Oligosaccharides
Catalog Number	Product Name		Pack Size
SLN404	Sialyl Lewisa (SLea) C31H51N2O32 · FW 820.83		0.5 mg   1 mg   5 mg
SLN403	Sialyl Lewisx (SLex) C31H51N2O32 · FW 820.83 Siayl Lewisx is an important antigen, which binds to the endothelial adhesion molecule E-selectin (formerly termed ELAM-1). It plays an important role in the inflammatory response, in which leucocytes are attracted to localised sites of infection or injury.		0.5 mg   1 mg   5 mg
SLN605	Sialyllacto-N-fucopentaose II C43H72N2O33 - FW 1145		20µg  100µg
SSN304	Sulfo Lewisa C20H34NSO18 Na · FW 631.55		0.5 mg   1 mg   5 mg
SLN406	Sialyl Lewisx-ß-methyl glycoside C32H54N2O23 - FW 834.77		0.5 mg   1 mg
SSN303	Sulfo Lewisx C20H34NSO18 Na · FW 631.55		0.5 mg   1 mg   5 mg

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